Hypoaldosteronism- A pathological condition due to insufficient production of aldosterone. It can be isolated, combined with a lack of other corticosteroids (for example, with Addison's disease or adrenogenital syndrome) or caused by a decrease in receptor sensitivity to the action of aldosterone, whose synthesis is not impaired (pseudohypoaldosteronism).
There are primary and secondary hypoaldosteronism. In both cases, aldosterone deficiency reduces the reabsorption of sodium and water in the renal tubules and increases the reabsorption of potassium and chlorine with the development of metabolic acidosis. Genetic aspects
Pseudohypoaldosteronism type I (* 264350, MLR, MSL gene mutations, 4q31.1, p or R)
- Pseudohypoaldosteronism type II - inherited hyperkalemia in combination with arterial hypertension, hyperchloremic acidosis and hyporenina (* 145260, ED.
- In infants, due to lack of 2-enzyme systems
- 18-hydroxydase deficiency
- 18-hydroxylase deficiency
- Can be combined with poly-glandular autoimmune syndrome type I
- Sodium loss and hypotension increase renin production (hyperrenin-hypoaldosteronism).